Search results for "Serum iga"
showing 4 items of 4 documents
Immune system adaptations during competition period in female cross-country skiers
2011
Stenholm, Johanna. Immune system adaptations during competition period in female cross-country skiers. Master’s Thesis in Exercise Physiology, Department of Biology of Physical Activity. University of Jyväskylä. 95pp. Purpose. This study was undertaken to characterize the extent of immune and endocrine changes in competition period and related to two competition weekends in well trained athletes in different parts of the competition period. An additional purpose was to evaluate if the changes in immunological variables would have an effect on the incidence of upper-respiratory-tract infections. The effect of the nutrition, nutrient and training status was also studied. Methods. Ten (10) nat…
Immunological investigations in two brothers with ataxia telangiectasia Louis-Bar
1976
Two of three brothers with the classical signs of ataxia telangiectasia were investigated for their immunological disorders at the ages of 13 and 16 years, respectively. The elder brother also suffers from autoimmune hemolytic anemia, a complication which has not yet been described in the course of ataxia telangiectasia. Immunological investigations made in both brothers showed a reduction in the number and function of T lymphocytes. The number of B lymphocytes was normal, among which there were cells staining for IgA, although serum IgA was absent. It seems possible that this phenomenon is caused by a disturbance in the process of maturation of lymphoid cells with a lack of differentiation…
Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts
2020
ObjectiveWe aimed to determine the predictive capacity and diagnostic yield of a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels for detecting small intestinal injury diagnostic of coeliac disease (CD) in adult patients.DesignThe study comprised three adult cohorts. Cohort 1: 740 patients assessed in the specialist CD clinic at a UK centre; cohort 2: 532 patients with low suspicion for CD referred for upper GI endoscopy at a UK centre; cohort 3: 145 patients with raised tTG titres from multiple international sites. Marsh 3 histology was used as a reference standard against which we determined the performance characteristics of an IgA tTG titre of ≥10×ULN for …
IgA anti-actin antibodies ELISA in coeliac disease: A multicentre study.
2007
Previous studies have demonstrated that serum anti-actin antibodies are a reliable marker of intestinal damage severity in coeliac disease.To validate in a multicentre study the clinical usefulness of serum IgA anti-actin antibody ELISA and its possible use in monitoring intestinal mucosa lesions during gluten-free diet.Four centres recruited 205 newly diagnosed coeliac disease patients with villous atrophy, 80 healthy controls and 81 "disease" controls. Twelve coeliac disease patients on gluten-free diet but with persistent symptoms underwent serum IgA anti-actin antibody assay and intestinal histology evaluation. IgA anti-actin antibody ELISA was performed with a commercial kit. All coeli…